Measuring Glucose without Needle Pricks

Pricking a finger every day is just part of everyday life for many diabetes patients… but not for much longer.

September 9, 2012
Manufacturing Group
Contract Manufacturing People/Facilities

A non-invasive measurement approach could release diabetes patients from the constant pain of daily finger pricks. The linchpin is a biosensor engineered by Fraunhofer researchers – a tiny chip combines measurement and digital analysis, and can be radioed to a mobile device.

Sticking yourself in the finger day after day. For many diabetics, this means of checking blood glucose is an everyday part of life. Especially for patients with Type-1 diabetes, who always have to keep a close eye on their levels, since their bodies are incapable of producing the insulin to break down the glucose in the blood. Several times a day, they have to place a tiny drop of blood on a test strip, as this is the only way they can ascertain the blood glucose value, so they can inject the correct amount of required insulin. This pricking is not only a burdensome, it may also cause inflammation or cornification of the skin. In addition, for pain-sensitive patients, the procedure is agony. 

The daily sticking of the finger may soon become outdated, thanks to a diagnostic system with Fraunhofer technology built-in. The underlying concept is a biosensor that is located on the patient’s body. It is also able to measure glucose levels continuously using tissue fluids other than blood, such as in sweat or tears. The patient could dispense with the constant needle pricks. In the past, such bioelectric sensors were too big, too imprecise and consumed too much power. Researchers at the Fraunhofer Institute for Microelectronic Circuits and Systems IMS in Duisburg have recently achieved a major breakthrough: They have developed a biosensor in nano-form that circumvents these hurdles. 

Diagnostic System in Miniature 
The principle of measurement involves an electrochemical reaction activated with the aid of an enzyme. Glucose oxidase converts glucose into hydrogen peroxide (H2O2) and other chemicals whose concentration are measurable with a potentiostat. This measurement is used for calculating the glucose level. The special feature of this biosensor: the chip, measuring just 0.5 x 2.0 millimeters, can fit more than just the nanopotentiostat itself. Indeed, Fraunhofer researchers have attached the entire diagnostic system to it.

“It even has an integrated analog digital converter that converts the electrochemical signals into digital data,” explains Tom Zimmermann, business unit manager at IMS. The biosensor transmits the data via a wireless interface, for example to a mobile receiver. Thus, the patient can keep a steady eye on his or her glucose level. “In the past, you used to need a circuit board the size of a half-sheet of paper,” Zimmermann says. “And you also had to have a driver. But even these things are no longer necessary with our new sensor.” 

Durable Biosensor 
The minimal size is not the only thing that provides a substantial advantage over previous biosensors of this type. In addition, the sensor consumes substantially less power. Earlier systems required about 500 microamperes at 5V; now, it is less than 100 microamperes. That increases the durability of the system – allowing the patient to wear the sensor for weeks, or even months. The use of a passive system makes this durability possible. The sensor is able to send and receive data packages, but it can receive power through radio frequency. 

Engineering of the glucose sensor was by the researchers at NovioSense BV, a Dutch medical technology firm. Since its manufacturing is available in such a cost-effective manner, it is best suited for mass production. These non-invasive measuring devices for monitoring blood glucose levels may become the basis for a particularly useful further development in the future: The biochip could control an implanted miniature pump that, based on the glucose value measured, indicates the precise amount of insulin to administer. That way, diabetes patients could say goodbye to incessant needle-pricks forever.