4 pediatric medical device developers receive seed funds
The TrachAlarm will alert a child's caregiver if a tracheostomy tube becomes dislodged.
Credit: Innovations Unlimited LLC

4 pediatric medical device developers receive seed funds

PPDC supports projects addressing point-of-care blood testing, tracheal dislodgement, peripheral intravenous catheters, respiratory distress syndrome.

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The Pennsylvania Pediatric Medical Device Consortium’s (PPDC) latest round of seed grants went to 4 companies developing medical devices for children. The 4 winners will each receive seed grants of $50,000.

The pediatric medical devices are:

  1. Rapid platelet monitoring system for newborns
  2. Tracheostomy tube dislodgement alarm
  3. Electrically based intravenous catheter insertion system
  4. Negative-pressure non-invasive ventilator for newborn intensive care

Funded by the U.S. Food and Drug Administration (FDA) and based at Children's Hospital of Philadelphia (CHOP), the PPDC provides know-how and seed funding to help innovators translate promising ideas into commercial medical devices for use in children. The PPDC is a collaboration involving CHOP, the McGowan Institute for Regenerative Medicine and sciVelo, both of the University of Pittsburgh, Drexel University, and the University of Pennsylvania.

The new round of awards is the sixth by the PPDC, following seed grants announced in February 2015, January 2016, January 2017, October 2017, and July 2018.

FloBio LLC of Philadelphia is developing a novel, point-of-care microfluidic chip and reader for rapid platelet function testing. Using minimal amounts of blood, the device will monitor anticoagulation pharmacology used in newborns undergoing corrective heart surgery or on life-sustaining circulatory or pulmonary support. The device will help to control thromboembolic events in infants and children suffering from congenital heart defects.

Innovations Unlimited LLC of Pennsauken, N.J. is creating the TrachAlarm to alert pediatric caregivers in a home care or other non-hospital setting if a patient's tracheostomy tube becomes dislodged. Tracheostomy tubes allow patients to breathe while undergoing treatment for certain chronic and congenital diseases. Fast recognition of tracheal dislodgement reduces risk for complications such as hypoxia, respiratory failure, cardiac arrest, and death.

The University of Pittsburgh is developing the ThreadRiteIV Catheter to improve the placement of peripheral intravenous catheters. These catheters are widely used for drug delivery in healthcare, but often require multiple attempts for insertion. ThreadRite detects blood vessels through a sophisticated system that measures differences in electrical resistance, and instantaneously alerts the operator of vessel entry via a light, audible, and vibratory signal. This eliminates the dependence on blood return for confirmation of insertion.

William J Weiss, PhD, of Penn State College of Medicine is leading efforts to develop the ThoraciCair to reduce the need for invasive and other labor-intensive techniques to treat respiratory distress syndrome in children. The ThoraciCair technology consists of a wearable device to move the chest wall and ventilate the patient by externally applying negative pressure. The ThoraciCair method creates a unique and novel platform for noninvasive ventilation strategies.